This one you're going to have to google on your own, it's in a few places. I've not followed the new storyline, so I'm like years out-of-date. But it was good.
By Randall Munroe, an ex nasa scientist, about life, math, the universe and romance with sarcasm and fun. He is also the writer of the books "What If? Serious Scientific Answers to Absurd Hypothetical Questions" , "Thing Explainer - Complicated Stuff in Simple Words" and "How to - Absurd Scientific Advice to Common Real-Life Problems"
A trans girl in highschool with real life problems and anxiety about not passing. Finding a group of queer friends and having many weird days. Made by Jocelyn Samara, a trans woman, more or less drawing about her own experiences.
After 2.5 years I still don't know if it counts as a webcomic, but I make Katabasis which is an illustrated action fantasy web serial. It’s about people with animal heads, magic, murder, and the relationship between an immortal woman and a monster.
On my site I also have a list of other comics and series that I follow, which I'll copy/paste here: